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Personalized Liver Cancer Radioembolization

Yttrium-90 (Y-90) radioembolization is being increasingly used for the treatment of advanced liver cancer. Accurate pretreatment dosimetry is necessary to determine the Y-90 activity to inject in order to maximize the dose to the tumor while limiting the dose to surrounding healthy parenchyma. Current dosimetry methods are not accurate nor precise, because they do not consider the non-uniform Y-90 microsphere distribution in the hepatic arterial tree as well as anatomy variations among the patients.



Develop personalized liver cancer radioembolization dosimetry, CFDose, based on blood flow simulation inside the hepatic arterial tree


  • Image processing

  • Computational fluid dynamics modeling

  • Pharmacokinetics modeling

  • Deep learning

  • Taebi, A., Berk, S., Roncali, E. (2021). Realistic boundary conditions in SimVascular through inlet catheter modeling. BMC Research Notes 14, 215.
    doi 10.1186/s13104-021-05631-7

  • Taebi, A., Janibek, N., Goldman, R., Pillai, R., Vu, C., Roncali, E. (2022) On the impact of injection distance to bifurcations on yttrium-90 distribution in liver cancer radioembolization, Journal of Vascular and Interventional Radiology.
    oi 10.1016/j.jvir.2022.03.006

  • Taebi, A., Vu, C.T., Roncali, E. (2020). Prediction of Blood Flow Distribution in Liver Radioembolization Using Convolutional Neural Networks. Presented in 2020 ASME IMECE, Portland, OR, V005T05A036.
    doi 10.1115/IMECE2020-24475

  • Taebi, A., Vu, C.T., Roncali, E. (2020). Estimation of Yttrium-90 Distribution in Liver Radioembolization using Computational Fluid Dynamics and Deep Neural Networks. IEEE Engineering in Medicine and Biology Society (EMBC), Montreal, QC, Canada, pp. 4974-4977.
    doi 10.1109/EMBC44109.2020.9176328

  • Roncali, E.,Taebi, A., Roudsari, B.S., Vu, C.T. (2020). Personalized dosimetry for liver cancer radioembolization based on computational fluid dynamics. Annals of Biomedical Engineering, 48(5): 1499-1510.
    doi 10.1007/s10439-020-02469-1

  • Roncali, E., Taebi, A., Spencer, B., Costa, G.C.A., Rusnak, M., Caudle, D., Roudsari, B., Pillai, R., Foster, C., Vu, C. (2020). Comparison of Y-90 liver dose distribution predicted with fluid dynamics with Y-90 PET, Journal of Nuclear Medicine 61 (supplement 1) 1308.

  • Roncali, E., Taebi, A., Rusnak, M., Spencer, B., Caudle, D., Foster, C., Vu, C.T. (2019). Personalized dosimetry for liver cancer radioembolization using computational fluid dynamics.European Journal of Nuclear Medicine and Molecular Imaging46 (Suppl 1): S134.
    doi 10.1007/s00259-019-04486-2

  • Taebi, A., Roudsari, B.S., Vu, C., Cherry, S.R., Roncali, E. (2019). Hepatic arterial tree segmentation: Towards patient-specific dosimetry for liver cancer radioembolization, Journal of Nuclear Medicine 60 (supplement 1) 122.

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